Tottenham lost the 2015 League Cup final against Chelsea, but have won their last two meetings, including a swaggering 3-1 success in the league at Wembley in November.
Maurizio Sarri’s side, who host the semi-final second leg on January 22, will give late fitness tests to Olivier Giroud (ankle) and winger Pedro (hamstring).
Blues boss Sarri is looking for his first trophy in his maiden season in charge.
The spotlight won’t just be on the managers however, amid fears vile anti-Semitic chants could overshadow the tie.
Last month, Chelsea fans were criticised by the club’s chairman Bruce Buck and investigated by UEFA after an offensive song about Tottenham’s Jewish fanbase was heard during a Europa League fixture.
The issue is complicated because many Tottenham fans use the offensive word themselves in celebratory chants about their Jewish links.
There have been other worrying incidents involving Chelsea supporters this season after a man was fined £965 and banned from football for three years after being found guilty of homophobic chants at Brighton.
Another Blues fan was accused of racially abusing Manchester City’s Raheem Sterling.